{"id":162,"date":"2024-06-12T12:18:30","date_gmt":"2024-06-12T12:18:30","guid":{"rendered":"https:\/\/raypeatbg.com\/?p=162"},"modified":"2024-06-12T12:18:31","modified_gmt":"2024-06-12T12:18:31","slug":"%d0%ba%d0%b0%d0%ba%d0%b2%d0%be-%d0%b2%d1%81%d1%8a%d1%89%d0%bd%d0%be%d1%81%d1%82-%d0%b5-%d0%b5%d0%bd%d0%b4%d0%be%d1%82%d0%be%d0%ba%d1%81%d0%b8%d0%bd","status":"publish","type":"post","link":"https:\/\/raypeatbg.com\/tr\/2024\/06\/12\/%d0%ba%d0%b0%d0%ba%d0%b2%d0%be-%d0%b2%d1%81%d1%8a%d1%89%d0%bd%d0%be%d1%81%d1%82-%d0%b5-%d0%b5%d0%bd%d0%b4%d0%be%d1%82%d0%be%d0%ba%d1%81%d0%b8%d0%bd\/","title":{"rendered":"Endotoksin asl\u0131nda nedir?"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Yayg\u0131n ba\u011f\u0131rsak bakterileri, amino asitler ve ya\u011f asitleri i\u00e7eren bir molek\u00fcl olan lipopolisakkarit \/LPS\/ \u00fcretir. Bu \u015fu \u015fekilde bilinir&nbsp;<strong>\"endotoksi\u0307n<\/strong>\". Endotoksin, bir bakterinin di\u011fer mikroorganizmalar taraf\u0131ndan \u00fcretilen baz\u0131 \"ekzotoksinlere\" kar\u015f\u0131 bir bariyer g\u00f6revi g\u00f6ren yap\u0131sal bir par\u00e7as\u0131d\u0131r. Ba\u011f\u0131rsaklar\u0131m\u0131z ve karaci\u011ferimiz, mevcut endotoksinlerin \u00e7o\u011funu dola\u015f\u0131ma ula\u015fmadan \u00f6nce etkili bir \u015fekilde yok etmek \u00fczere tasarlanm\u0131\u015ft\u0131r. Safra asitleri ba\u011f\u0131rsakta deterjan etkisi g\u00f6stererek ba\u011f\u0131rsa\u011f\u0131n emici y\u00fczeylerini endotoksinin zararl\u0131 etkilerinden korur.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Normal \u015fartlar alt\u0131nda karaci\u011fer, endotoksinin kan dola\u015f\u0131m\u0131na girmesini ve \u00f6strojenin h\u00fccreler taraf\u0131ndan tutulmas\u0131n\u0131 \u00f6nlemek i\u00e7in \u00e7al\u0131\u015f\u0131r. Yetersiz beslenme, hipotiroidizm, protein eksikli\u011fi ve streste karaci\u011fer \u00f6strojenin tamamen etkisiz hale getirilmeden ge\u00e7mesine izin verir. Bu detoksifikasyon sisteminin endotoksinleri inhibe etmesi, \u00f6strojeni sistemik olarak y\u00fckseltmesinin yaln\u0131zca bir yoludur. \u00d6strojenin t\u00fcm biyolojik eylemlerinde uyar\u0131c\u0131 oldu\u011funu ve \u00e7o\u011fu dokuda bu uyar\u0131c\u0131 eylemin oksidatif strese neden oldu\u011funun g\u00f6sterildi\u011fini unutmay\u0131n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Tom Brewer, protein eksikli\u011finin Vit A ve B eksikli\u011fine yol a\u00e7abilece\u011fini ve a\u00e7aca\u011f\u0131n\u0131, bunun da karaci\u011ferin ins\u00fclin ve \u00f6strojeni etkisiz hale getirmesini engelleyerek birikime ve toksisiteye yol a\u00e7aca\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Herhangi bir stres enflamasyonu art\u0131r\u0131r ve enflamasyon da endotoksin al\u0131m\u0131n\u0131 art\u0131r\u0131r!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ne kadar zararl\u0131?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1. Ba\u011f\u0131rsaklar\u0131 tahri\u015f eden her \u015fey endotoksin emilimini art\u0131racakt\u0131r<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2. Karaci\u011fer endotoksine ba\u011fl\u0131 \u00f6strojeni detoksifiye etmezse, \u00f6strojen prolaktin, ACTH, pankreatik beta h\u00fccreleri, NO, TNF, IL ve PUFA'lardan prostaglandin yapan enzimleri uyaracakt\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3. Bu da ba\u011f\u0131rsak ge\u00e7irgenli\u011fini art\u0131rarak otoimm\u00fcniteye yol a\u00e7acakt\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4. Endotoksin antitiroid, imm\u00fcnosupresiftir ve GI sistemde demir retansiyonunun artmas\u0131n\u0131 te\u015fvik eder.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">5. Yo\u011fun egzersiz ve a\u00e7l\u0131\u011f\u0131n laktik asit ve amonyak \u00fcretimini art\u0131rd\u0131\u011f\u0131 ve bunun da ince ba\u011f\u0131rsakta bakteriyel endotoksin emilimini art\u0131rabildi\u011fi g\u00f6sterilmi\u015ftir. Bu durum hipoglisemik s\u0131\u00e7anlarla yap\u0131lan deneylerde g\u00f6sterilmi\u015ftir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">6. Karragenan endotoksin \u00fcretimini ve emilimini art\u0131racakt\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">7. Endotoksin kandaki \u00f6strojen seviyelerinde art\u0131\u015fa neden olur. \u00d6strojen alb\u00fcmin ve suyu kandan \u00e7eker ve dokulara iter, bu da d\u00fc\u015f\u00fck kan hacmi, hiponatremi, \u00f6dem, kan p\u0131ht\u0131la\u015fmas\u0131nda art\u0131\u015f... vb. ile sonu\u00e7lan\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">8. PUFA gibi sindirilemeyen g\u0131dalar\u0131n varl\u0131\u011f\u0131nda, fermantasyon yoluyla laktat \u00fcretilecek ve bu da serotonin ve endotoksin \u00fcretecektir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">9. Endotoksin h\u00fccreleriniz i\u00e7in uyar\u0131c\u0131d\u0131r, Ca ve \u00f6strojen tutmalar\u0131na neden olur, suya olan ilgilerini art\u0131r\u0131r ve bir\u00e7ok MSS ve endokrin bozuklu\u011fa yol a\u00e7ar.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">10. Endotoksin lipid peroksidasyonunu art\u0131r\u0131r ve glukoz oksidasyonunu inhibe eder<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Referanslar:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">http:\/\/www.jlr.org\/content\/50\/1\/1.full http:\/\/textbookofbacteriology.net\/endotoxin.html http:\/\/www.drlera.com\/bacterial_diseases\/bacterial_endotoxins.htm http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20592272 http:\/\/diabetes.diabetesjournals.org\/content\/57\/6\/1470.full http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8450032 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8335381<\/p>","protected":false},"excerpt":{"rendered":"<p>Yayg\u0131n ba\u011f\u0131rsak bakterileri, amino asitler ve ya\u011f asitleri i\u00e7eren bir molek\u00fcl olan lipopolisakkarit \/LPS\/ \u00fcretir. Bu \"endotoksin\" olarak bilinir. Endotoksin, di\u011fer mikroorganizmalar taraf\u0131ndan \u00fcretilen baz\u0131 \"ekzotoksinlere\" kar\u015f\u0131 bir bariyer g\u00f6revi g\u00f6ren bakterinin yap\u0131sal bir par\u00e7as\u0131d\u0131r. Ba\u011f\u0131rsaklar\u0131m\u0131z ve karaci\u011ferimiz, mevcut endotoksinlerin \u00e7o\u011funu dola\u015f\u0131ma ula\u015fmadan \u00f6nce etkili bir \u015fekilde yok etmek \u00fczere tasarlanm\u0131\u015ft\u0131r. Safra... <a class=\"more-link\" href=\"https:\/\/raypeatbg.com\/tr\/2024\/06\/12\/%d0%ba%d0%b0%d0%ba%d0%b2%d0%be-%d0%b2%d1%81%d1%8a%d1%89%d0%bd%d0%be%d1%81%d1%82-%d0%b5-%d0%b5%d0%bd%d0%b4%d0%be%d1%82%d0%be%d0%ba%d1%81%d0%b8%d0%bd\/\">Okumaya devam et <span class=\"screen-reader-text\">Endotoksin asl\u0131nda nedir?<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"iawp_total_views":139,"footnotes":""},"categories":[3],"tags":[80,81],"class_list":["post-162","post","type-post","status-publish","format-standard","hentry","category-3","tag-80","tag-81","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u041a\u0430\u043a\u0432\u043e \u0432\u0441\u044a\u0449\u043d\u043e\u0441\u0442 \u0435 \u0435\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u043d? - \u0440\u0435\u0439 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