{"id":150,"date":"2024-06-11T06:28:37","date_gmt":"2024-06-11T06:28:37","guid":{"rendered":"https:\/\/raypeatbg.com\/?p=150"},"modified":"2024-06-11T06:28:38","modified_gmt":"2024-06-11T06:28:38","slug":"%d0%b4%d0%be%d0%b7%d0%b8%d1%80%d0%b0%d0%bd%d0%b5-%d0%bd%d0%b0-%d0%b1%d0%b8%d0%be-%d0%b8%d0%b4%d0%b5%d0%bd%d1%82%d0%b8%d1%87%d0%b5%d0%bd-%d0%bf%d1%80%d0%be%d0%b3%d0%b5%d1%81%d1%82%d0%b5%d1%80%d0%be-2","status":"publish","type":"post","link":"https:\/\/raypeatbg.com\/en\/2024\/06\/11\/%d0%b4%d0%be%d0%b7%d0%b8%d1%80%d0%b0%d0%bd%d0%b5-%d0%bd%d0%b0-%d0%b1%d0%b8%d0%be-%d0%b8%d0%b4%d0%b5%d0%bd%d1%82%d0%b8%d1%87%d0%b5%d0%bd-%d0%bf%d1%80%d0%be%d0%b3%d0%b5%d1%81%d1%82%d0%b5%d1%80%d0%be-2\/","title":{"rendered":"Dosage of bioidentical progesterone"},"content":{"rendered":"

PART 1<\/u><\/strong><\/p>\n\n\n\n

Dr. Ray Pete on the menstrual cycle<\/u><\/strong><\/p>\n\n\n\n

\"The menstrual cycle in a woman, in which brief estrogen dominance is followed by prolonged exposure to progesterone, which is a very important factor in the regeneration of the cells of the brain and other organs, including those of the reproductive organs. The daily rhythms of hormones and metabolism are part of the regulation of cell renewal.\"<\/p>\n\n\n\n

\"Cells respond to estrogen stimulation by producing a variety of molecules including the \" progesterone\" receptor protein. When progesterone enters the cell by binding to these proteins, the estrogen stimulation is interrupted by a series of reactions in which the estrogen receptors are broken down, and in which estrogen becomes soluble in water through the activation of sulfate- or sugar acid-binding enzymes. Estrogen thus leaves the cell and is incorporated into the bloodstream, where by deactivating another type of enzyme it is prevented from re-entering or forming in the cell, oxidizing it to a less active form. Progesterone terminates the cellular functions of estrogen with extreme accuracy.\"<\/p>\n\n\n\n

\"In polycystic ovaries, menopausal symptoms, arthritis, angina, multiple sclerosis, some types of dementia, migraine and emphysema, rapid and effective relief can be achieved simply by improving cellular energy metabolism.\"<\/p>\n\n\n\n

\"For example, the follicular phase is a period during which small amounts of steroids are produced by the ovaries, almost until the end of the phase when estrogen rises just before ovulation. The luteal phase is characterized by high synthesis of progesterone and estrogen. Many publications describe the follicular phase as a period of high estrogen and the luteal phase as a period of low estrogen, which is the opposite of the real situation.\"<\/p>\n\n\n\n

\"Each month a productive crisis occurs in the ovaries with the formation of estrogen, prostaglandins, carbon monoxide, and other signal substances causing rapid local and systemic changes in water, hormones, and nutrients accumulating around the egg. Subsequently, as the follicle ruptures and the egg is released, inflammatory stress is regulated by the massive synthesis of an anti-inflammatory, anti-stress substance, progesterone. These monthly processes are associated with growth, they are part of the epigenetic development of the organ.<\/p>\n\n\n\n

Most, if not all, of the substances associated with ovarian physiology are tied to the diseases of stress and aging, which develop in direct correlation with the lack of mechanisms to deal with inflammatory processes and recovery from them to a stable state. The ovary is a major source of estrogen that can induce stimulated, activated, and proliferative states in every tissue of the body, although it acts primarily on the uterus, breasts, and pituitary. However, the ovaries can also produce large amounts of the protective progesterone, which interrupts the inflammatory effects of estrogen on various tissues and organs, mostly by suppressing the proteins that retain estrogen in cells (especially the \"estrogen receptor\"), but also by altering the activities of many enzymes. Growth-related processes in the ovaries lead to continuous epigenetic processes in other organs, causing noticeable changes in their structure every month.\"<\/p>\n\n\n\n

\"The estrogen dominance required to initiate the reproductive cycle, with cell proliferation (formation of new cells) in the uterine lining, breasts, and pituitary gland, is otherwise not beneficial to the body, and is controlled and regulated during pregnancy by constantly increasing progesterone production.\"<\/p>\n\n\n\n

\"Mink that mate in the winter do not implant the fertilized egg in the uterus until the vernal equinox, when their progesterone suddenly rises and allows the uterus and embryo to begin gestational processes. Progesterone provides the oxygen needed for successful implantation of the embryo, while estrogen and serotonin lower oxygen levels inside the uterus.<\/p>\n\n\n\n

Under normal conditions, the premenstrual (luteal) phase of the menstrual cycle resembles pregnancy, as a period of progesterone dominance in which an abundance of progesterone causes a decrease in the estrogen content of cells. The luteal phase is actually the first stage of pregnancy and if there is embryo implantation, all the processes that begin from ovulation progress gradually until birth. If embryo implantation does not take place, progesterone dominance during the luteal phase ceases, allowing estrogen to enter the tissues and induce menstruation. The sudden drop in progesterone production before menstruation is similar to the drop in hormone synthesis just before childbirth. The same are the causes of premenstrual syndrome and can lead to preeclampsia, toxemia of pregnancy, eclampsia, and postpartum depression if not corrected by progesterone production by the placenta. Similar problems are associated with menopause. Whenever progesterone production is lowered, tissues are susceptible to estrogen.<\/p>\n\n\n\n

There are several causes of progesterone deficiency. Thyroid problems, cholesterol, insufficient vitamin A are among the most common. It can also be caused by insufficient exposure to light, by increased intake of polyunsaturated fats, which negatively affect the thyroid and gonads. High serotonin can also cause progesterone deficiency.\"<\/p>\n\n\n\n

\"In the ovary and uterus, the healthy alternation of stimulation and rest usually continues for many years, and in rodents often ends in a state of 'permanent exuberance' in which the period of stimulation is not terminated in the usual way, by the production of progesterone. In humans, menopause is analogous in that follicle stimulating hormone (FSH) from the pituitary is in excessive amounts, the ovaries continue to produce estrogen but cannot produce progesterone, and the pituitary cannot convert FSH to LH (luteinizing hormone). In rodents, it is known that the condition of \"permanent heat\" is due to chronically elevated estrogen levels, whereas in humans it is denied that it is the cause of menopause and aging.<\/p>\n\n\n\n

An increase in the amounts of the main instigator of inflammation, serotonin, which is associated with the influence of estrogen, may have similar effects on the reproductive cycle (Cooper, et al., 1986). The industry has invested with the resources necessary to manipulate medical research and the public into believing that reproductive aging is primarily related to estrogen deficiency.\"<\/p>\n\n\n\n

\"Stress uses progesterone and can cause menstrual cycles to stop. Girls who start regular exercise (like dancing) before puberty have later sexual development.\"<\/p>\n\n\n\n

\"Stress, trauma and shock trigger inflammatory processes that cause long-term damage to organs, including the liver. Progesterone supplementation after injury protects against the increase of TNF (tumor necrosis factor), IL-6 (interleukin-6), and the leakage of liver enzymes (Kuebler, et al., 2003). Progesterone has similar effects on the brain, lungs, and other organs. During the normal menstrual cycle, IL-6 is inversely related to progesterone levels (Angstwurm, et aI., 1997).\"<\/p>\n\n\n\n

Dr. Pete's progesterone dosing recommendations<\/u><\/strong><\/p>\n\n\n\n

For superficial treatment of sunburned skin, acne, dark spots, oil with progesterone can be applied directly to the affected areas.<\/p>\n\n\n\n

Since progesterone has none of the side effects of the other hormones (apart from changing the menstrual cycle if taken at the wrong time of the month), the main procedure should be to use it in sufficient quantities until the symptoms disappear. This means using it only between ovulation and menstruation unless the symptoms are too serious, or if skipping a cycle is not important to you.<\/p>\n\n\n\n

If there is an enlarged thyroid gland, progesterone prompts the secretion and discharge of stored colloids and can cause temporary hyperthyroidism, which is a healing process. Supplementation with thyroid hormones can be used to shrink the goiter prior to starting progesterone.<\/p>\n\n\n\n

Normal amounts of progesterone prompt thyroid secretion, while its deficiency, especially when too much estrogen is present, causes an increase in thyroid.<\/p>\n\n\n\n

Some mention euphoria as a \"side effect\" of progesterone use, but it is simply an indication of a good physiological state. To avoid unexpected anaesthesia, the correct dose should be determined by taking 10 mg (3-4 drops) at a time, allowing it to spread across the membranes in the mouth. The dose should be repeated after 10 minutes and so on until the symptom is controlled.<\/p>\n\n\n\n

An increased estrogen\/progesterone ratio (should be 1 part estrogen to 10 parts progesterone) is the cause of the unpleasant symptom of thin and bluish skin. Decreases in thyroid hormones is one cause of the increase in estrogen, and when high estrogen is combined with decreased thyroid function, the skin appears pale and bloodless.<\/p>\n\n\n\n

Symptoms in women are most common around ovulation and in the premenstrual week, when the estrogen\/progesterone ratio is normally highest. Puberty, early 20s, late 30s, and menopause are the ages when this ratio is commonly disturbed. These are also the ages when the thyroid is most vulnerable.<\/p>\n\n\n\n

Individuals who suffer from progesterone (and\/or thyroid) deficiency possess the tendency of developing other problems at different times. With cyclical depression or migraine at age 22, there is a high chance of developing breast disease at a later stage, or pregnancy problems are possible. Women with a history of severe symptoms are most likely to have health problems around menopause. Prenatal exposure to poorly balanced hormones can predispose the child to later hormonal imbalances.<\/p>\n\n\n\n

Increased stress, dark days without sunlight, toxins and nutrient deficiencies are among the factors thatcan block the synthesis of progesterone and increase estrogen. A very common cause of elevated estrogen is a deficiency of dietary proteins, since with their insufficiency, the liver cannot detoxify estrogen.<\/p>\n\n\n\n

Diets high in protein and vitamin A intake, as well as taking thyroid hormone replacements, can reduce progesterone levels. In these women, no effect is seen even from taking 100 mg of progesterone. They need to change their diet to normalize their estrogen, prolactin, and cortisol levels.<\/p>\n\n\n\n

Progesterone stimulates the ovaries and adrenal glands to produce more progesterone, it also activates the thyroid gland. It is not necessary to take progesterone indefinitely, except in women with removed ovaries. In weaker women in the post-menstrual period, 10 mg per day should be sufficient to prevent progesterone deficiency.<\/p>\n\n\n\n

In 10% progesterone solution in vitamin E, one drop contains about 3 mg of progesterone. Normally, the body produces 10-20 mg per day. A dose of 3 or 4 drops usually brings its blood levels to normal, but this dose may be repeated during the day to control symptomatology.<\/p>\n\n\n\n

For general use, it is most economical and effective to take dissolved progesterone in vitamin E orally, for example a few drops on the tongue or in the lips, or to rub it into the gums. (This is also good for the general health of the gums.) Their membranes are very thin and this is why progesterone can easily and quickly enter the bloodstream. When ingested, vitamin E allows it to be absorbed through the walls of the stomach and intestines.<\/p>\n\n\n\n

As mentioned above, superficial application of the oil helps heal sunburned skin. For the superficial treatment of arthritis, osteoporosis, tendonitis, bursitis and varicose veins, to speed absorption it is best to apply a few drops of olive oil to the area and then spread the progesterone - vitamin E solution on and around the affected area.\"<\/p>\n\n\n\n

\"Progesterone supplements\"<\/u><\/strong><\/p>\n\n\n\n

Symptomatics<\/strong>A: For tendonitis, bursitis, arthritis, sunburns, progesterone and vitamin E can be applied topically after applying a little olive oil to the skin for easier distribution of the progesterone solution.<\/p>\n\n\n\n

For migraine, it is taken orally at the onset of a symptom.<\/p>\n\n\n\n

About PMS<\/strong>A: The normal pattern of progesterone secretion during the month is for the ovaries to produce a large amount during the second two weeks of the menstrual cycle (i.e., days 14-28), beginning at ovulation and ending at the onset of menstruation. Subsequently, less is produced (in the remaining two weeks). Usually the body produces about 30 mg per day during the second two weeks. The progesterone supplement solution contains approximately 3 or 4 mg of it in one drop. Three or four drops, or 10-15 mg of progesterone is usually enough to normalize its levels in the body. This amount can be taken during the 14-28 day period of the menstrual cycle, and repeated once or twice during the day to overcome symptoms. Since progesterone's primary mechanism of action involves its opposition to estrogen, smaller amounts of it may be effective when estrogen production is low. However, if estrogen is very high, even large amounts of progesterone would have no clear effect. In this case, it is of primary importance to regulate estrogen metabolism by improving diet, correcting thyroid hormone deficiency, etc. (Unsaturated fats act anti-thyroid and synergize with estrogen.)<\/p>\n\n\n\n

Perimenopause<\/strong>A: Symptoms and changes in the body leading up to menopause are associated with a decrease in progesterone production, at a time when estrogen is in large amounts. Taking progesterone cyclically - two weeks on, then two weeks off, would maintain the onset of menstrual cycles. Three or four drops providing 10 or 12 mg of progesterone is a normal intake for the day, but some women prefer to repeat this amount. Progesterone is always more effective when the diet contains adequate amounts of protein, and when it does not contain large amounts of unsaturated fat.<\/p>\n\n\n\n

Postmenopause<\/strong>A: Some women continue to cycle progesterone after menopause because it is an important regulator of pituitary and brain function. The pituitary gland has an influence on the adrenal glands and other organs, and progesterone has a protective function against the unbalanced action of prolactin, cortisol, and adrenal androgen hormones. Progesterone's effect on the pituitary apparently contributes to its protective action against osteoporosis, hypertension, hirsutism (excessive hair), etc. Some women continue to use progesterone without interruption after the onset of menopause because of its protective anti-stress effects. Weaker people find that two or three drops a day is enough, but these amounts can be repeated again for symptom relief. Adequate amounts of protein in the diet and a good thyroid support the body to produce its own progesterone, even if the ovaries are removed, the adrenal glands and brain continue to produce it.<\/p>","protected":false},"excerpt":{"rendered":"

PART 1 Dr. Ray Peet on the Menstrual Cycle \"The monthly cycle in woman, in which a brief estrogen dominance is followed by a prolonged exposure to progesterone, which is a very important factor in the regeneration of the cells of the brain and other organs, including those of the reproductive organs. The daily rhythms of hormones and metabolism are part of... Continue reading Dosage of bioidentical progesterone<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"iawp_total_views":700,"footnotes":""},"categories":[3],"tags":[60,75,8,4],"class_list":["post-150","post","type-post","status-publish","format-standard","hentry","category-3","tag-60","tag-75","tag-8","tag-4","entry"],"yoast_head":"\n\u0414\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u0431\u0438\u043e \u0438\u0434\u0435\u043d\u0442\u0438\u0447\u0435\u043d \u043f\u0440\u043e\u0433\u0435\u0441\u0442\u0435\u0440\u043e\u043d - \u0440\u0435\u0439 \u043f\u0438\u0439\u0442 \u0431\u044a\u043b\u0433\u0430\u0440\u0438\u044f<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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